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Clinical Studies

Mucosal Irritation Potential of Personal Lubricants Relates to Product Osmolality
as Detected by the Slug Mucosal Irritation Assay.
Sexually Transmitted Diseases. 2008 May;35:512-516

This study found the “The irritation potency (assessed by the mucus production) of the lubricants showed a significant, quadratic relationship with the product osmolality (P = 0.001; R (2) = 0.99). Femglide, a hypo-osmotic lubricant (32 mOsm/kg), caused a negative mucus production. (Pre-Seed), an iso-osmotic lubricant (316 mOsm/kg), caused no changes. Two moderately hyperosmotic lubricants, Replens and K-Y jelly (2143 and 2463 mOsm/kg), induced mild and moderate irritation, respectively. The highly hyperosmotic lubricant Astroglide (5848 mOsm/kg) resulted in severe irritation and tissue damage. Commonly used personal lubricants show a full range of mucosal irritation potential, which is related to product osmolality.”

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